Degradation from within

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چکیده

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Biochem 1998;5:317–22. 4. Oellerich M, Shipkova M, Schütz E, Weber L, Tönshoff B, Armstrong VW, et al. Pharmacokinetic and metabolic investigations of mycophenolic acid in pediatric patients after renal transplantation: implications for therapeutic drug monitoring. Ther Drug Monit 2000;22:20–6. 5. Pescovitz MD, Conti D, Dunn J, Gonwa T, Halloran P, Sollinger H, et al. Intravenous mycophenolate ...

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Specific degradation of proteins within the secretory pathway

Background: The endoplasmic reticulumassociated degradation (ERAD) is a cellular mechanism to eliminate misfolded proteins. Results: Fusion of a target-binding domain to a fragment of the ERAD-associated protein SEL1L induces specific degradation of secretory and membrane-bound target proteins. Conclusion: The new recombinant proteins (degradins) efficiently induce degradation of targets within...

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ژورنال

عنوان ژورنال: Science-Business eXchange

سال: 2014

ISSN: 1945-3477

DOI: 10.1038/scibx.2014.191